The atomic, molecular, and optical (AMO) physics community at Stanford spans the departments of Physics, Applied Physics, and Electrical Engineering.  Browse our site to learn about research groups, events, and more.

Upcoming Events

Thomas Juffmann ( Laboratoire kastler brossel, ENS, Paris)
Multi-pass microscopy - approaching Heisenberg limited sensitivity in optical and electron microscopy
Monday, April 3, 2017
4:00 pm - 5:30 pm
Location: Spilker 232
Abstract
The number of biological macromolecules with a structure solved by cryogenic-electron microscopy (cryo-EM) increases dramatically each year. However, many small and weakly scattering protein structures remain out of reach, as electron dose induced specimen damage limits the achievable spatial resolution [1].
Improved sensitivity and spatial resolution can be obtained employing quantum measurement strategies. A quantum optimal approach to measuring small phase shifts, as induced by a thin protein, is to pass each probe particle through the specimen multiple times [2].
Employing self-imaging cavities, this idea can be applied to widefield microscopy [3]. We show post-selected optical birefringence and absorption measurements beyond the shot-noise limit and discuss the applicability of multi-pass microscopy to cryo-EM. Our EM simulations [4] show that multi-pass TEM allows for a tenfold damage reduction in imaging small proteins.

[1] Glaeser et al, Nat. Methods, 13, 1, 28-32 (2016).
[2] Giovannetti et al., Physical Review Letters 96, 10401 (2006).
[3] Juffmann et al, Nature Communications 7, 12858 (2016).
[4] Juffmann et al, arXiv:1612.04931 (2016).
Immanuel Bloch (Max Planck Institute of Quantum Optics)
Physics/AP Colloquium
Tuesday, April 11, 2017
4:30 pm - 6:00 pm
Location: Hewlett Teaching Center, room 200

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