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Multi-pass microscopy - approaching Heisenberg limited sensitivity in optical and electron microscopy
Improved sensitivity and spatial resolution can be obtained employing quantum measurement strategies. A quantum optimal approach to measuring small phase shifts, as induced by a thin protein, is to pass each probe particle through the specimen multiple times .
Employing self-imaging cavities, this idea can be applied to widefield microscopy . We show post-selected optical birefringence and absorption measurements beyond the shot-noise limit and discuss the applicability of multi-pass microscopy to cryo-EM. Our EM simulations  show that multi-pass TEM allows for a tenfold damage reduction in imaging small proteins.
 Glaeser et al, Nat. Methods, 13, 1, 28-32 (2016).
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 Juffmann et al, Nature Communications 7, 12858 (2016).
 Juffmann et al, arXiv:1612.04931 (2016).